Sync Times with Microsoft
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If you change the policy protection mode from Monitor Only or Detect and Remediate mode to Prevent (Inline) mode, it takes time to start protecting in Prevent (Inline) mode. It could take up to an hour, depending on the number of protected users in the Avanan account.
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When adding a user to the scope of a Prevent (inline) policy that is not set to All Users and Groups, it may take up to 1 hour for emails from this user to be inspected inline.
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When a new user is added to Microsoft 365, administrators can include them in the policy scope within 10 minutes or it might take up to 24 hours.