In manual mode, you must change the policy to Protect (Inline) before moving to Office 365 configurations.
To configure Protect (Inline) protection mode, follow Steps 7-9 below.
To configure the Protect (Inline) policy:
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Log into the Email Security
Administrator Portal.
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Go to Policy > click Create a New Rule or open a existing rule for Office 365.
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Select Protect (Inline) protection mode.
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In the Scope section, select the users and/or group of users for whom the policy is applicable:
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To apply the policy to all users and groups in your organization, enable All Users and Groups checkbox.
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To apply the policy to specific users or groups, select the users/ groups and click Add to Selected.
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To exclude specific users or groups from the policy, select the required users/groups and click Add to Excluded.
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Under Advanced Configuration select Configure excluded IPs manually in mail flow rule checkbox.
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Click Save and apply.