By default, all file are scanned when they are opened or used.
You can configure Trusted Processes as exceptions. When a trusted process accesses a file, the file is not scanned. Exclude a process only if you fully trust it and are sure it is not malware.
To configure trusted processes:
C:\Program Files\MyTrustedDirectory\MyTrustedProgram.exe
%programdata%\MyTrustedProgram.exe
The trusted program shows in the Trusted Processes list.